Pdf crosspresentation of antigens by dendritic cells. Crosspresentation is the process where exogenous antigens are ingested and processed to generate peptide t cell epitopes that are presented by mhc class i mhci molecules 9, 10. Dcs are especially known for their ability to crosspresent, as they process and present exogenous antigens on mhci molecules much more efficiently than other phagocytes. Pdf crosspresentation by dendritic cells researchgate. Pdf dendritic cell maturation and crosspresentation. Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex mhc i molecules. Current concepts of antigen crosspresentation ncbi. Dendritic cells dcs have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can. Antigen crosspresentation describes the process through which dendritic cells dcs acquire exogenous antigens for presentation on mhc class i molecules.
Oxidized lipids block antigen crosspresentation by. Dendritic cells are the professional apcs of our immune system that are key in linking innate and adaptive immunity. Monitoring antigen crosspresentation by human dendritic cells. Molecular mechanisms of dendritic cell crosspresentation. Dendritic cells are the professional apcs of our immune system that are key in. Summary as a population, dendritic cells dcs appear to be the best. We discuss the antigenic requirements for crosspresentation, the phenotype of the antigen presenting cell apc, the cellular interactions and molecular signals involved in crosspriming, and the factors that direct the immune system toward tolerance or immunity.
The ability to crosspresent has been thought of as a feature of specialized dc subsets. Antigen crosspresentation by dendritic cell subsets. In vivo, cross presentation is mainly carried out by specific dendritic cell dc subsets through an. Adjuvants enhancing crosspresentation by dendritic cells frontiers. Differential use of autophagy by primary dendritic cells specialised in crosspresentation. Crosspresentation of cellassociated antigens by mhc. It is now known that crosspresentation of exogenous antigens on major histocompatibility complex mhc class i occurs through several distinct cellular pathways. Crosspresentation of antigens is a unique feature of dcs, which is critically important for antitumor immunity. Emerging data, however, suggest that the crosspresenting ability of each dc subset is tuned by and dependent on several factors, such as dc location.
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