Pdf crosspresentation of antigens by dendritic cells. Consistent with this, the speed of vesicle maturation is inversely correlated with the efficacy of crosspresentation, with a gradient from conventional dendritic cells cdcs, crosspresenting. Monitoring antigen crosspresentation by human dendritic cells. Pdf crosspresentation by dendritic cells researchgate.
Antigen crosspresentation describes the process through which dendritic cells dcs acquire exogenous antigens for presentation on mhc class i molecules. Adjuvants enhancing crosspresentation by dendritic cells. In vivo, cross presentation is mainly carried out by specific dendritic cell dc subsets through an. Adjuvants enhancing crosspresentation by dendritic cells frontiers. Dendritic cells capture antigens from tumor cells into endosomal. Oxidized lipids block antigen crosspresentation by.
Antigen crosspresentation by dendritic cell subsets. Dendritic cells are the professional apcs of our immune system that are key in. Crosspresentation of cellassociated antigens by mhc. Differential use of autophagy by primary dendritic cells specialised in crosspresentation.
Crosspresentation is the process where exogenous antigens are ingested and processed to generate peptide t cell epitopes that are presented by mhc class i mhci molecules 9, 10. Pdf dendritic cell maturation and crosspresentation. Dendritic cells dcs have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can. Tumor antigen presentation requires crosspresentation of antigens from the tumor cells by dc. We discuss the antigenic requirements for crosspresentation, the phenotype of the antigen presenting cell apc, the cellular interactions and molecular signals involved in crosspriming, and the factors that direct the immune system toward tolerance or immunity. The ability to crosspresent has been thought of as a feature of specialized dc subsets. Summary as a population, dendritic cells dcs appear to be the best. Dendritic cells are the professional apcs of our immune system that are key in linking innate and adaptive immunity.
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